If the dopaminergic defects can mostly explain all the cognitive symptoms or this phenomenon just co-occur with other anatomical and biochemical changes remains unknown. Nigrocaudate dysfunction is related to lower memory performance while dopamine depletion in the anterior putamen is related to poorer attention performance. Our findings suggest that reduced DAT availability in both caudate and putamen is related to reduced performances in some memory and attention/executive tasks. Lower scores in RAVLT/short-term recall were also significantly associated with lower uptake values in the more affected caudate and reduced performance in Trail Making Test part B was related with reduced DAT values in the less affected anterior putamen. After controlling the effect of age, disease duration and education, lower scores in Rey's Auditory-Verbal Learning Test (RAVLT)/immediate recall were significantly related with lower uptake values in the less affected striatum and more affected caudate. The significance level was set at P values of < 0.02.
Multiple linear regression controlling the effect of age, disease duration and education was applied. They underwent TRODAT-1 SPECT/CT and a comprehensive neuropsychological battery including attention/executive and memory tests. Fifty-four non-demented PD patients were enrolled. This study was designed to assess whether cognitive performances are related to dopamine active transporter (DAT) availability in non-demented PD subjects. Parkinson's disease (PD) is clinically characterized by motor symptoms, however, specific cognitive impairments are common and poorly understood.
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